In situations where recurrent miscarriages and implantation failures occur, more in-depth diagnostic investigations are advisable. These can help identify reasons for the lack of pregnancy success and develop tailored treatment approaches based on these findings.
Genotyping of KIR (Killer Immunoglobulin-like Receptor) and HLA-C (Human Leukocyte Antigen-C) gene variants is a powerful diagnostic method. It enables the analysis of compatibility between maternal NK cell KIR receptors in the endometrium and the partner’s HLA-C molecules in the embryo.
Different KIR genotypes and HLA-C typing classes offer a wide range of combinations. Some combinations, such as KIR AA and HLA-C2, are associated with recurrent miscarriages and implantation failures. These incompatibilities can even increase the risk of pregnancy complications like pre-eclampsia.
Genotyping is done through blood tests on the prospective mother and partner (or sperm donor). This allows the identification of KIR and HLA-C types. In the case of egg donation, the donor’s HLA-C type is also determined.
The application of KIR-HLA-C compatibility is a tailored approach. In a personal consultation with Dr. Christos Roukoudis, the appropriate steps for your case will be discussed and determined.
If incompatibility is identified, targeted measures can be taken. Transferring a single embryo may minimize the mother’s immune reaction to foreign molecules. Additionally, medication therapy to suppress the immune response can enhance the treatment’s success probability.
KIR-HLA-C genotyping can also be significant in egg or sperm donation. The donor’s HLA-C genotype can be matched for compatibility with the prospective mother’s KIR receptors.
Do you have any more questions about KIR-HLA-C Compatibility? We’re here to provide you with all the answers you need.
Obstetrician – Gynecologist
Fertility Specialist
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