Assisted hatching is a laboratory technique in which the embryo’s outer shell (zona pellucida) is carefully thinned using a highly precise laser. This shell naturally protects the embryo during early development, but it must open at the right stage (“hatching”) to allow implantation into the uterine lining.
By facilitating this process, assisted hatching may support implantation, particularly in selected cases such as advanced maternal age, previous implantation failure, or embryos with a thicker zona pellucida.
The procedure is performed under strict laboratory conditions, using targeted laser application without direct contact with the embryo’s cells, minimizing potential stress to the embryo.
Assisted hatching may be recommended for patients with repeated implantation failure or in cases where the embryo’s zona pellucida appears thickened or less likely to hatch naturally.
It can also be considered in specific situations such as advanced maternal age or after previous unsuccessful IVF cycles, where implantation may be impaired.
The decision to use assisted hatching is always individualized, based on the patient’s clinical history and embryo characteristics.
While assisted hatching may support implantation in selected cases, it should be applied with careful clinical consideration.
Current evidence does not show a clear increase in overall multiple pregnancy rates directly attributable to assisted hatching. The primary determinant of multiple pregnancy remains the number of embryos transferred.
As with any laboratory procedure, assisted hatching is used selectively and within a controlled clinical setting, ensuring that treatment decisions are tailored to the individual patient and aligned with best practice guidelines.
When discussing assisted hatching, it is important to consider that the underlying causes of developmental disorders in children conceived through assisted reproductive techniques are multifactorial.
Current evidence suggests that these outcomes are more likely related to parental factors—such as genetic background, maternal age, or severe male factor infertility—rather than to the assisted hatching procedure itself.
Assisted hatching is a well-established laboratory technique and, when applied appropriately, does not appear to independently increase the risk of developmental abnormalities.
The success of assisted hatching also depends on the expertise of the embryology team. The procedure requires precise technique, optimal timing, and strict laboratory conditions.
In our partner laboratories, assisted hatching is performed by experienced embryologists using advanced laser technology and standardized protocols, ensuring consistent quality and a high level of safety.
We provide expert guidance on the Assisted Hatching technique.
Our team will guide you with care, every step of the way.